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EC number: 445-040-3 | CAS number: -
In a GLP compliant eye irritation study, performed according to OECD guideline 405, test substance (0.1 g) was placed in the conjunctional sac of the left eye of 3 New Zealand White rabbits. Scoring of irritation effects was performed approximately 1, 24, 48 and 72 hours, as well as 7, 10, 14, 17, and 21 days after test item instillation. The instillation of the test substance into the eye resulted in mild, early-onset and transient ocular changes, such as reddening of the conjunctivae and sclerea, discharge and chemosis. These effects were reversible and were no longer evident 7 days after treatment. Red staining of the treated eyes produced by the test item was observed in all animals at the 1 -hour examination and persisted up to the observation 21 days after treatment. No abnormal findings were observed in the iris of any animal at any of the examinations, no corrosion was observed at any of the measuring intervals and no clinical signs were observed.
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