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Hydrolysis

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Description of key information

With a half-life of 212 hours at pH7 and a temperature of 25 °C, the test substance may be considered hydrolitically stable.

Key value for chemical safety assessment

Half-life for hydrolysis:
212 h
at the temperature of:
25 °C

Additional information

A GLP-compliant hydrolysis test was performed according to OECD guideline 111. The hydrolysis of the test item was performed at 50.0 ± 0.1 °C at each of pH 4.0, pH 7.0 and pH 9.0 (RCC 2003). The test substance was found to be stable at pH 4.0 at 50°C. Therefore, no further testing was performed at this pH-value. The test substance was not stable at pH 7.0 and further testing was performed at elevated temperatures in order to calculate the rate constant and the half-life time of the hydrolysis at 25 °C (by means of the Arhenius equation). At pH 9.0, the test substance was very unstable at 50°C. Therefore, no further testing was performed at this pH. In conclusion, The test substance is stable at pH 4.0. Its half-life time is longer than one year at 25 °C. The test substance at pH 7.0 has a half-life time of 212 hours at 25 °C. The test substance at pH 9.0 has a half-life time shorter than one day at 25 °C.