Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The 21-day NOEC is 11 mg/L in Daphnia magna.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
11 mg/L

Additional information

In a GLP compliant daphnia magna reproduction test, performed according to OECD Guideline 211, the effect of the test substance on survival and reproduction of daphnia magna was investigated. Daphnids were exposed to nominal concentration of 1.1, 3.4, 11, 34, and 110 mg/L of the test substance for 21 days under semi-static conditions. The analytically determined test substance concentrations in the analysed test media varied in the range from 98% to 106% of the nominal values at the start and in the range from 93 to 102% at the end of the test medium renewal periods. The test substance was sufficiently stable in the test water at least over the longest renewal periods of 72 hours.

In the control and at the lower test concentrations up and including 11 mg/L the survival of the test animals at the end of the test was 100%. At the next higher test concentration of 34 mg/L the survival was 30%. At the highest test concentration of 110 mg/L, all test animals were dead at the observation on Day 19. The time of the first brood was not affected up to and including the highest test concentration of 110 mg/L. No inhibitory effect of the test substance on the mean reproduction rate was determined up to and including the test concentration of 34 mg/L, which was the highest test concentration with surviving daphnids. At these test concentrations, the mean reproduction rates were even slightly higher compared to the control. Taking into account the survival and the reproduction of the test animals, the NOEC was 11 mg/L.