Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-652-4 | CAS number: -
Eurofins Product Safety Laboratory (EPSL 2008) conducted a primary skin irritation test with rabbits to assess the potential for nickel hydroxycarbonate to cause irritation following a single topical application (carried out according to OECD Procedure 326 guidelines and using GLP standards). Nickel hydroxycarbonate was applied as a dry paste (0.5 g in a 50/50 w/w mixture in distilled water) to the clipped skin of three healthy, female white rabbits for 4 hours. After the 4-hour exposure, the Draize method was used to assess dermal irritation at approximately 30-60 minutes; 24, 48, and 72 hours. At 30-60 minutes after patch removal, all three animals demonstrated very slight erythema at the treatment site, but no edema was observed. Overall severity and incidence of irritation was found to decrease with time. No erythema or irritation was evident in any of the animals by 72 hours. The three animals appeared healthy and active during the study. Other than dermal irritation, no other signs of abnormal behavior, gross toxicity, or adverse pharmacologic effects were observed. The Primary Dermal Irritation Index calculated for nickel hydroxycarbonate was 0.5, and the substance was classified as slightly irritating to the skin. STUDY RATED BY AN INDEPENDENT REVIEWER
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again