Registration Dossier
Registration Dossier
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EC number: 204-707-7 | CAS number: 124-64-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Published test report from National Toxicology Program (US). Evaluated data from a reliable secondary source (US-CPSC).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.5265 (The Salmonella typhimurium Bacterial Reverse Mutation Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- EC Number:
- 204-707-7
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- Cas Number:
- 124-64-1
- Molecular formula:
- C4H12O4P.Cl
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium chloride
- Reference substance name:
- Tertrakis(hydroxymethyl)phosphonium chloride
- IUPAC Name:
- Tertrakis(hydroxymethyl)phosphonium chloride
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- not applicable
- Additional strain / cell type characteristics:
- not specified
- Remarks:
- no growth without histidin or mutagenic treatment
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 of Aroclor 1254-induced male Sprague-Dawley rat and male Syrian hamster liver
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- see attached bachground material
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- see attached bachground material
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not valid
- Positive controls validity:
- valid
- Additional information on results:
- NTP short-term test data reveal no mutagenic effect of THPC in bacteria. The chemical was not mutagenic in the Salmonella/microsome assay with the preincubation protocol in strains TA98, TA100, TA1535, or TA1537 with or without metabolic activation from S9 of Aroclor 1254-induced male Sprague-Dawley rat and male Syrian hamster liver (Appendix J , Table J1)
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'. Remarks: in separate
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
THPC is not mutagenic in the Salmonella reverse mutation assay w/wo metabolic activation.
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