Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-707-7 | CAS number: 124-64-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (GLP)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402, EC B.3, OPPTS 870.1200
- Deviations:
- yes
- Remarks:
- 24 hours exposure
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- EC Number:
- 500-057-6
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- Cas Number:
- 27104-30-9
- IUPAC Name:
- 500-057-6
- Details on test material:
- AFLAMMIT SAP, batch no 175594 806, expiration date 30 June 2008, manufacturer is Thor GmbH_ Speyer_ Germany.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 2000 mg/kg bw
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 5m, 5fm
Results and discussion
In vivo
Results
- Irritation parameter:
- other: scar formation
- Basis:
- animal #3
- Time point:
- other: day 9 post exposure
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not reversible
- Remarks on result:
- other: female rats
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 2000 mg/kg bw of Aflammit SAP is corrosive to skin after 24 hours exposure. Scar formation becomes visible at day 9 post application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
