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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published data from a peer reviewed journal. Evaluated data from a reliable secondary source (US-CPSC).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1980
Report date:
1980
Reference Type:
secondary source
Title:
Unnamed
Year:
1987
Report date:
1987
Reference Type:
secondary source
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(hydroxymethyl)phosphonium chloride
EC Number:
204-707-7
EC Name:
Tetrakis(hydroxymethyl)phosphonium chloride
Cas Number:
124-64-1
Molecular formula:
C4H12O4P.Cl
IUPAC Name:
tetrakis(hydroxymethyl)phosphonium chloride

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
1500 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No statistic evaluation.
Mortality:
Death was reported after dermal application of >1500 mg/kg bw in rats.
Clinical signs:
skin slouthing and hyperemia at doses > 1500 mg/kg bw
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information dermal LD50 (rat): > 1500 mg/kg bw Criteria used for interpretation of results: US CPSC / US OSHA
Conclusions:
dermal LD50 (rat): > 1500 mg/kg body weight
Executive summary:

dermal LD50 (rat): > 1500 mg/kg body weight