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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1992-1994
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Evaluated data from a reliable secondary source (WHO 2000 as well as US-CPSC).

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Reference Type:
secondary source
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
not specified
GLP compliance:
not specified
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Reference substance name:
Tetrakis(hydroxymethyl)phosphonium sulphate(2:1)
EC Number:
259-709-0
EC Name:
Tetrakis(hydroxymethyl)phosphonium sulphate(2:1)
Cas Number:
55566-30-8
IUPAC Name:
bis[tetrakis(hydroxymethyl)phosphonium] sulfate
Details on test material:
75% THPS (nominal) aqueous solution

In vivo test system

Test animals

Species:
guinea pig
Strain:
Dunkin-Hartley
Sex:
not specified

Results and discussion

Positive control results:
THPS (75%) was assessed for skin sensitization using the Magnusson & Kligman Maximisation test (OECD 406). Fourteen out of 20 animals
challenged with the test substance were sensitized (Guest, 1994b). These data clearly demonstrate a sensitization potential for THPS (75%).

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
No. with + reactions:
14
Total no. in group:
20
Remarks on result:
other: Reading: 1st reading. Group: test group. No with. + reactions: 14.0. Total no. in groups: 20.0.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information