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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
The irritant/corrosive effects of Lactofen were tested on the eye of rabbits. The method used complied with the OECD - Guideline for Testing of Chemicals No.405 -"Acute Eye Irritation/Corrosion"; for reasons of animal welfare a sequential testing strategy was followed.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: solid, high viscous
Details on test material:
Test compound: Lactofen
Chemical name: (2-ethoxy-I-methyl'-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
CAS no.: 77501-63-4
Molar mass: 461.78 g/mol
Molecular formula: C19H15ClF3NO7
Appearance: solid, high viscosity, brown
Storage: room temperature
Content of test substance: 95.54 % (not used for calculations)

Confirmation of the identity of the test compound was performed.

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
72 hours
Number of animals or in vitro replicates:
3 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0
Max. score:
2
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0.3
Max. score:
3
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Other effects:
no other effects reported

Any other information on results incl. tables

Lactofen is not irritating to eyes. There were no systemic intolerance reactions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

The irritant/corrosive effects of Lactofen were tested on the eye of rabbits. The method used complied with the OECD - Guideline for Testing of Chemicals No.405 -"Acute Eye Irritation/Corrosion"; for reasons of animal welfare a sequential testing strategy was followed.

Eye irritations were scored and recorded approximately at 1, 24, 48 and 72 hours post application.

The degree of ocular lesions was recorded as specified by DRAIZE and any serious lesions or toxic effects other than ocular lesions were also recorded and fully described.

The mean cormeal opacity score after 24, 48, and 72 hours was 0, the iris score = 0, the redness conjunctivae score = 0.3 and the chemosis conjunctivae score = 0.

Therefore Lactofen is not irritating to eyes. There were no systemic intolerance reactions.