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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983

Materials and methods

Principles of method if other than guideline:
The acute inhalation toxicity of PPG-844 was assessed by exposing 10 rats (5 males and 5 females), for a period of 4 hours, to an atmosphere containing a respirable aerosol of the test substance. The animals were observed for mortality, clinical signs, food and water consumption. At the end of the 14-day observation period the rats were subjected to a detailed macroscopic examination.
GLP compliance:
yes
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Details on test material:
The test substance was a brown viscous liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
head only
Vehicle:
other: 10% acetone
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
Group 1 (control)
Group 2 (vehicle control)
Group 3 (PPG-844)

Atmosphere concentration of PPG-844:
By gravimetric analysis: 3.6 g/m³
By HPLC analysis: 3.4 g/m³
No. of animals per sex per dose:
5 mala and 5 female animals per group
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 3.4 mg/L air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables

Mortality: There were no deaths related to exposure to PPG-844

Clinical signs: a) during exposure: no adverse signs were visible b) brown staining of the fur and poor groming was noted in the rats exposed to PPG-844. These signs persisted for 2 days (males) or 11 days (females).

Body weight: no effect

Food consumption: reduced for all groups on the day following exposure

Water consumption: markedly increased water consumption for 5 days (males) or 3 days (females)

Macroscopic pathology: no abnormalities were seen in any rat

Applicant's summary and conclusion

Executive summary:

The acute inhalation toxicity of PPG-844 was assessed by exposing 10 rats (5 males and 5 females), for a period of 4 hours, to an atmosphere containing a respirable aerosol of the test substance. The animals were observed for mortality, clinical signs, food and water consumption. At the end of the 14-day observation period the rats were subjected to a detailed macroscopic examination.

LC50 (4 hours) for PPG-844: In excess of 3.4 g/m³ which was the highest attainable aerosol concentration.