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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
other:
Adequacy of study:
supporting study
Study period:
2012
Rationale for reliability incl. deficiencies:
other: Short description on comprehensive studies available via the internet by US EPA and pubchem.ncbi.nlm.nih.gov

Data source

Reference
Reference Type:
secondary source
Title:
lactofen - Compound Summary (CID 62276)
Author:
US EPA and Pubchem NCBI
Year:
2012
Bibliographic source:
http://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:3:0::no:1,3,31,7,12,25:p3_xchemical_id:2666

Materials and methods

Principles of method if other than guideline:
Teratology studies; no further data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
other: rabbits and rats
Strain:
not specified

Administration / exposure

Vehicle:
not specified
Details on mating procedure:
No data
Duration of treatment / exposure:
No data
Frequency of treatment:
daily
Duration of test:
no data
No. of animals per sex per dose:
no data

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

Executive summary is derived from the following internet links on 2012 -11 -09.

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62276#x321

http://www.epa.gov/iris/subst/0280.htm

References of individual studies:

PPG Industries. 1983a. MRID No. 00132885. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

PPG Industries. 1982b. MRID No. 00117566. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

PPG Industries. 1985c. MRID No. 00150367, 00163307. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

2-Generation Reproduction - rat: Reproductive NOEL=50 ppm (2.5 mg/kg/day); Reproductive LEL=500 ppm (25 mg/kg/day) (reduced mean pup weight, increased relative and absolute weight of brain, heart, liver, spleen and testes; brown pigment in liver; extramedullary hematopoeisis, hyperplasia of spleen); core grade minimum (PPG Industries, 1983a)

Teratology - rat: Fetotoxic NOEL=50 mg/kg/day; Fetotoxic LEL=150 mg/kg (bent ribs); Teratogenic NOEL=150 mg/kg/day; Maternal NOEL=50 mg/kg/day; Maternal LEL=150 mg/kg/day (post implantation loss; reduced body weight); core grade minimum (PPG Industries, 1982b)

Teratology - rabbit: Maternal NOEL=4 mg/kg/day; Maternal LEL=20 mg/kg/day (decreased food consumption); Fetotoxic NOEL=20 mg/kg/day; core grade minimum (PPG Industries, 1985c)