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EC number: 616-466-9 | CAS number: 77501-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 43 FR 37336, Part 163.81-2
- Principles of method if other than guideline:
- The test article was applied to the clipped and abraded skin of 5 male and 5 female albino rabbits at a dose level of 2 grams per kg bw. the animals were observed for mortality, clinical signs and body weight gain. A gross necropsy was performed of all animals sacrifieced on day 14.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
- EC Number:
- 616-466-9
- Cas Number:
- 77501-63-4
- Molecular formula:
- C19H15ClF3NO7
- IUPAC Name:
- (2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
- Test material form:
- liquid: viscous
- Details on test material:
- very viscous, brown, oily liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals were applied a dose of 2000 mg/kg bw
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
All animals survived the 14-day duration of the study.
One female gained body weihgt consistantly from day 0 to day 14. One male and one other female lost body weight from day 0 to day 7. The remaining 4 males and 3 females lost body weight from day 0 to day 7 and regained at least 40% of this lost body weight from day 7 to day 14.
Very slight and/or well defined erythema was observed for all animals from days 1 or 2 as late as day 11. No other dermal reactions were observed during the study.
Gross necropsy examinations revealed solitary or multiple, red or red-brown discolorations of the skin at the test sites of one male and 3 females. A diffuse, green discoloration of the lung was also observed upon necropsy examination of one ot these females. Necropsy examination of one other male revealed a solitary, tan depression on the stomach. No other abnormalities were observed upon necropsy examinations of all animals sacrificed on day 14.
Applicant's summary and conclusion
- Executive summary:
The test article was applied to the clipped and abraded skin of 5 male and 5 female albino rabbits at a dose level of 2 grams per kg bw. the animals were observed for mortality, clinical signs and body weight gain. A gross necropsy was performed of all animals sacrifieced on day 14. All animals survived the 14-day duration of the study.
Therefore the LD50 is > 2000 mg(kg bw (rabbit, m+f)
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