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EC number: 908-343-6 | CAS number: -
Table 1: Results of the clinical chemistry haematology
Control group 1 (0 ppm)
Control group 2 (0 ppm)A
Mean cell volume (fl)
Mean cell haemoglobin (pg)
Total protein (g/L)
Red blood cell count (10e12/L)
A) 25 ppm group is compared to control group 2 since animals were treated simultaneously. *p <0.05, **p <0.01 (student's t-test, two-sided)
Table 2: Microscopic findings
Control (0 ppm)
Necrosis and inflammation (sqamous epithelium, anterior region of nasal cavity)
3/5 males, 2/5 females
Necrosis and inflammation (sqamous epithelium, anterior regions of nasal cavity)
4/5 males, 4/5 females
Mononuclear cell infiltration
Increase in perivascular neurophil infiltration
2/5 males, 1/5 females
1/5 males, 2/5 females
A repeated dose inhalation toxicity study was performed with male and female Alpk:APfSD (Wistar-derived) rats exposed to hydrogen peroxide vapours for 6 hours per day, 5 days per week for a period of 28 days at concentrations of 2.03, 10.3 or 23.3 ppm. The study was carried out under GLP conditions and in accordance with OECD Guideline No. 412. Treatment of a group exposed initially to 58.1 ppm and subsequently to 27.3 ppm was terminated before schedule due to the toxicity of the test material. Clinical observations were consistent with the material being a respiratory tract irritant (reddened noses, stains around the nose, abnormal respiratory noise) and in general the time to onset, incidence and severity of clinical signs increased with exposure concentration and repeated exposure. Males exposed to 23.3 ppm hydrogen peroxide showed lower food consumption and body weight gain compared to controls. Minimal changes in albumin and total protein blood levels were found in males and females exposed to 23.3 ppm. Histopathological, treatment-related changes were seen in the anterior-most regions of the nasal cavity lined with squamous epithelium, where minimal to slight necrosis (with associated inflammation) and rhinitis were seen in animals exposed to 10.3 and 23.3 ppm hydrogen peroxide. Inflammation and epithelial erosion in the larynx and increased perivascular neutrophil infiltration in the lungs were considered unlikely to be related to treatment in the absence of a clear dose response relationship. The no observed effect level (NOEL) for the study was considered to be 2.03 ppm hydrogen peroxide (corresponding to 2.9 mg/m3).
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