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EC number: 908-343-6
CAS number: -
Bioconcentration refers to the accumulation of a substance
dissolved in water by an aquatic organism (definition from section
R.126.96.36.199 of ECHA's guidance document on "Information requirements and
chemical safety assessment" R7c p. 9). As the reaction mass of calcium
carbonate and calcium dihydroxide and calcium peroxide is a solid
inorganic multi-constituent substance which undergoes dissociation and
hydrolysis in aqueous media, this means that Ca2 +, OH- and
hydrogen peroxide are the species to be taken into account
when assessing its potential to bioconcentrate.
* H2O2: Hydrogen peroxide is reactive and a
polar substance with a short half-life, and the log Kow value of
hydrogen peroxide is estimated at approximately –1.5. These
properties indicate negligible potential of bioconcentration of hydrogen
peroxide (cf., European Union Risk Assessment Report: hydrogen peroxide;
European Chemicals Bureau, Institute for Health and Consumer Protection,
2nd Priority List Volume 38; EUR 20844 EN; page 35).
Moreover, the enzyme catalase is almost ubiquitously distributed
in biotic systems enabling the organisms to convert hydrogen peroxide
into water and oxygen.
* Ca(OH)2: Exposure to calcium dihydroxide actually
comes down to exposure to calcium ions and hydroxyl ions. There will be
no intake of calcium dihydroxide as such from an aquatic medium, nor
will calcium dihydroxide prevail under its original form in the
organisms. Moreover, both the intake of the essential element calcium
and the internal pH of an organism are actively regulated (homeostasis).
Therefore, this endpoint is considered not to be relevant for calcium
dihydroxide, and a bioconcentration test in fish is not deemed required.
In conclusion, the reaction mass of calcium carbonate and calcium
dihydroxide and calcium peroxide is an inorganic multi-constituent
substance that hydrolyses in water. The constituents and hydrolysis
products are not bioaccumulative. Studies to determine the
bioaccumulation of the reaction mass of calcium carbonate and calcium
dihydroxide and calcium peroxide are therefore not needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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