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EC number: 908-343-6
CAS number: -
studies on toxicokinetics are available. However, toxicokinetic
information can be derived from the physicochemical properties and the
chemical reactivity of the constituents of the reaction mass of calcium
carbonate, calcium dihydroxide and calcium peroxide.
reactions that take place when the different components of the reaction
mass of calcium carbonate, calcium hydroxide and calcium peroxide are
dissolved in water are equally applicable when the systemic availability
of the reaction mass of calcium carbonate, calcium hydroxide and calcium
peroxide is assessed. Indeed, the chemicals can only be systemically
available to the organs when they can be transported to different parts
of the body, which requires dissolution of the chemicals in the blood.
consequence, the chemical reactions driving the environmental fate and
the environmental toxicity of the reaction mass of calcium carbonate and
calcium dihydroxide and calcium peroxide are also relevant for the
assessment of the toxicokinetics of this multi-constituent substance.
2 OH-+ H2O2
H2O + O2
++ 2 OH-
CaCO3 --> Ca2++
the read-across from test results available for hydrogen peroxide and
calcium dihydroxide is considered justified not only for
ecotoxicological but also for toxicological endpoints. According
to the applicable chemical reaction (see above), the amount of hydrogen
peroxide formed is equimolar to the amount of calcium peroxide present
in the reaction mass. As the concentration of calcium peroxide in the
reaction mass is ca. 75%, 100 mg of the reaction mass contains 75 mg of
calcium peroxide, which corresponds to 1,04 mmol of calcium peroxide.
Therefore, 1.04 mmol (= 35,36 mg) of hydrogen peroxide is formed upon
dissolution of 100 mg of the reaction mass.
It is to
be noted that hydrogen peroxide itself rapidly degrades both
in tissues of first contact and blood due to the presence of catalase in
these environments. Catalase is an iron-containing enzyme present in
blood and many tissues. Its biological role is to scavenge the hydrogen
peroxide that is formed as a byproduct in many normal
calcium dihydroxide that is both present in the reaction mass and formed
upon hydrolysis of the calcium peroxide will mainly cause effects
related to the pH change. This elevated pH value implies that the
substance will show the typical local effects associated with basic
solutions. The systemic effects of the hydroxyl anion are mitigated by
the buffer capacity of the blood.
Because hydrogen peroxide is rapidly
degraded in the blood, while calcium hydroxide is neutralized due to the
buffer capacity, the reaction mass is not expected to be systemically
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