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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: literature, too little details on experimental design given

Data source

Reference
Reference Type:
publication
Title:
Fragrance Compound Geraniol Forms Contact Allergens on Air Exposure. Identification and Quantification of Oxidation Products and Effect on Skin Sensitization
Author:
L.Hagvall, C.Backtorp, S.Svensson, G.Nyman, A.Borje and A.-T.Karlberg
Year:
2007
Bibliographic source:
Chem. Res. Toxicol. 2007, 20, 807-814

Materials and methods

Principles of method if other than guideline:
acc. to Kimber et al, 1995
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

In vivo test system

Test animals

Species:
mouse

Study design: in vivo (LLNA)

Vehicle:
not specified
Concentration:
0.5%, 5%, and 20%
No. of animals per dose:
4

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: 0.5%: SI = 0.68 5%: SI = 1.8 20%: SI = 5.7 EC3 = 9.7%
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: 0.5%: 600 dpm/node 5%: 1550 dpm/node 20%: 5060 dpm/node

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
According to the authors, Neral is considered a moderate sensitizer.