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EC number: 203-379-2
CAS number: 106-26-3
total recovery of radioactivity from the excreta urine and feces, from
total skin and from unresorbed citral at the skin surface was 42.1% in a
guinea pig without pre-treatment (C) and 47.7% in a guinea pig that had
been subjected to an induction treatment with citral (A). Amounts
evaporated from the site of application, excreted via exhalation of 14CO2,
or deposited in body tissues were not recorded in this study. The
amounts absorbed into the skin within 16 hrs p.a. were 23.9% (C) and
27.5% (A). The amount of 14C in the stratum corneum was
comparable in all groups (10.0-12.2 %). There was a greater variation in
the penetration to deeper skin layers between the single animals
(6.4-10.5%). However, the 14C-recovery after stripping the
stratum corneum from the deeper skin layers was incomplete compared to 14C-acitivity
in total skin. Additionally, the values were recorded from single
animals only, so that the values may represent individual variation.
distribution (% of initial deposit) of14C-citral in
sensitized guinea pigs and controls
Test group (1 animal/group)
Sensitization: induction treatment
Skin sample preparation step
Unresorbed citral (cotton swab)
Soluble skin before dialysis
Ratio soluble to insoluble proteins
Total 14C recovered
FCA: Freund's complete adjuvant
soluble to insoluble proteins =100x [Step 9]/[Step9] + [Step6]
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