(Z)-3,7-dimethylocta-2,6-dienal

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1974

Materials and methods

Study type:

study with volunteers

Principles of method if other than guideline:

A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 25 healthy male and female volunteers. Application was under occlusion to the same site on the forearms of all subjects for five alternate-day 48 hour periods. Patch test sites were pretreated for 24 hours with 5% aqueous sodium lauryl sulfate under occlusion. Following a ten day rest period, a challenge patch was applied to a fresh site for 48 hours under occlusion. Reactions to challege were read at patch removal and 24 hours after patch removal.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Neral

IUPAC Name:

Neral

Method

Route of administration:

dermal

Results and discussion

Results of examinations:

Vehicle was petrolatum
5 % sensitization effects
17/25 positive.

Applicant's summary and conclusion

Conclusions:

5 % sensitization effects
17/25 positive.