2-methylimidazole

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Principles of method if other than guideline:

BASF test

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylimidazole

EC Number:

211-765-7

EC Name:

2-methylimidazole

Cas Number:

693-98-1

Molecular formula:

C4H6N2

IUPAC Name:

2-methyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 2-Methylimidazol

Test animals

Species:

mouse

Strain:

other: Kisslegg

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Doses:

200, 250, 320, 400, 800 and 1600 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 24 and 48 hours and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 350 mg/kg bw

Based on:

test mat.

Mortality:

200 and 250 mg/kg group: none of the animals died
320 mg/kg group: 1/10 animals died
400 mg/kg group: 9/10 animals died
800 and 1600 mg/kg group: all/10 animals died

Clinical signs:

Junmping cramps, morphed tails, dyspnoea and lying on the stomach

Body weight:

Normal body weight gain

Gross pathology:

Substance remaining in and agglutination of the abdominal cavity