Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Principles of method if other than guideline:
BASF test
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylimidazole
EC Number:
211-765-7
EC Name:
2-methylimidazole
Cas Number:
693-98-1
Molecular formula:
C4H6N2
IUPAC Name:
2-methyl-1H-imidazole
Details on test material:
- Name of test material (as cited in study report): 2-Methylimidazol

Test animals

Species:
mouse
Strain:
other: Kisslegg
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
200, 250, 320, 400, 800 and 1600 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 24 and 48 hours and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 350 mg/kg bw
Based on:
test mat.
Mortality:
200 and 250 mg/kg group: none of the animals died
320 mg/kg group: 1/10 animals died
400 mg/kg group: 9/10 animals died
800 and 1600 mg/kg group: all/10 animals died
Clinical signs:
Junmping cramps, morphed tails, dyspnoea and lying on the stomach
Body weight:
Normal body weight gain
Gross pathology:
Substance remaining in and agglutination of the abdominal cavity

Applicant's summary and conclusion