2-methylimidazole

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

The tested concentration (0.26 mg/L) is low.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

BASF test (Inhalation hazard test). The test was performed in priniple as described in OECD Guideline 403. The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temerature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted gassdisc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order toverify the results, the test was repeated once.

GLP compliance:

no

Test type:

other: Inhalation-risk test (IRT)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylimidazole

EC Number:

211-765-7

EC Name:

2-methylimidazole

Cas Number:

693-98-1

Molecular formula:

C4H6N2

IUPAC Name:

2-methyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 2-Methylimidazol in Schuppen
- Substance number: 77/697

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Firma Wiga, Sulzfeld
- Diet: Herilan MRH (firma: EGGERSMANN, KG, Rinteln), ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
- Vapour generation: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted gassdisc in a glass cylinder for 8 hours.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

0.26 mg/L

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 0.26 mg/L air

Based on:

test mat.

Remarks:

(initial - final substance weight) / (200 l/h * 7h)

Exp. duration:

7 h

Remarks on result:

other: none of the animals died

Mortality:

None of the animals died during the observation period.

Clinical signs:

other: No abnormalities were detected.

Body weight:

Normal body weight gain was observed.

Gross pathology:

No abnormalities were detected.