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EC number: 223-829-1
CAS number: 4090-51-1
The submission substance was assessed for possible aquatic
toxicity in reliable tests (all reliability category 1) on freshwater
algae (Scenedesmus subspicatus), freshwater invertebrates (Daphnia
magna, acute), freshwater fish (zebra fish, acute) and sewage treatment
plant microorganisms (activated sludge respiration inhibition test, 3
hours). In all these tests, nominal limit concentrations far above the
actual water solubility of the submission substance were used (77 or
1000 mg/L). However, no signs of toxicity were observed in any of these
tests. Thus, judging from these results terrestrial toxicity of the
submission substance is unlikely. To ascertain this and in line with
REACH guidance R.7c, chapter R.7.11.5, a possible chronic toxicity of
the submission substance on earthworm reproduction was assessed. In the
reliable (reliability category 1) test performed compliant to GLP no
statistically significant effects on mortality, biomass or reproduction
of Eisenia fetida were observed up to the highest tested concentration.
Thus, the NOEC (56 d; mortality, biomass, reproduction) was determined
to be larger or equal to 1000 mg/kg soil dw. In conclusion, taking
together nontoxic properties of the submission substance towards aquatic
(micro)organisms as well as soil macroorganisms (chronic test), toxicity
of the submission substance towards terrestrial organisms can safely be
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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