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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Relevant methodological deficiencies (only 4 h of exposure, only 4 animals)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
acute dermal irritation and toxicity test
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
EC Number:
223-829-1
EC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
Cas Number:
4090-51-1
Molecular formula:
C10H20O5P2S2
IUPAC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
4 h
Doses:
5000 mg/kg
No. of animals per sex per dose:
4
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: exposure duration 4 h

Applicant's summary and conclusion

Conclusions:
Under the conditions of this study the LD50 in male rats was > 5000 mg/kg. Due to relevant methodological deficiencies (only 4 h of exposure, only 4 animals), no definite conclusions can be drawn.
Executive summary:

 4 rats of unknown sex were treated with 5000 mg/kg test substance (occlusive) for 4 h and observed for 14 days. No mortality and no other effects were reported. Therefore under the conditions of this study the LD50 in rats was > 5000 mg/kg.