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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Short communication with limited data documetation
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Type of study / information:
Test on inhibition of cholinesterase activity
Principles of method if other than guideline:
enzyme test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
EC Number:
223-829-1
EC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
Cas Number:
4090-51-1
Molecular formula:
C10H20O5P2S2
IUPAC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide

Results and discussion

Any other information on results incl. tables

The test item was insoluble in usual solvents. It was tested in acetone aqueous suspension and did not inhibit the activity of the cholinesterase up to the highest tested concentration of 1 x 10epx-2 M. Parathion was used as positive control and showed an IC50 of 2-4 x 10exp-4 M.

Applicant's summary and conclusion