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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Standard protocol with some deficiencies in data reporting
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
Skin irritation test according to Draize
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
EC Number:
223-829-1
EC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
Cas Number:
4090-51-1
Molecular formula:
C10H20O5P2S2
IUPAC Name:
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide

Test animals

Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
no details

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
not specified
Controls:
no
Amount / concentration applied:
0,5 g
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6
Details on study design:
Exposure period 24 h in this study, compared to 4 h in OECD guideline 404
Use of impervious wrap
SCORING SYSTEM:
Evaluation of results according to ETAD score system: Values for erythema and edema (maximal score: 4 each) for intact and abraded skin at 24 and 72 h are added and divided by 4 to give the primary irritation score:
0 - 0.5:       non irritant
0.6 - 3.0:    slightly irritant
3.1 - 5.0:     moderately irritant
5.1 - 8.0:    severely irritant

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Remarks:
intact skin
Basis:
mean
Time point:
other: 24, 72 h
Score:
0
Max. score:
4
Reversibility:
other: no irritation observed on intact skin
Remarks on result:
other: Based on the evaluation scheme of guideline OECD 404, the effects on intact skin would indicate an irritation score of 0 (based on restricted observations at 24 and 72 h only)
Irritation parameter:
overall irritation score
Remarks:
intact and abraded skin
Basis:
mean
Time point:
other: 24, 72 h
Score:
0.25
Max. score:
8
Reversibility:
other: edema of grade 1 observed in all animals after 72 h on abraded skin
Remarks on result:
other: ETAD score

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of this study the test substance was not irritating to skin
Executive summary:

The test substance was applied to the skin of 6 albino rabbits for 24 h under an occlusive wrap. Skin reaction were evaluated at the end of exposure (time point 24 h) and 48 h thereafter (time point 72 h) according to the ETAD classification system. No skin irritation was observed in this study.