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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
other: company data
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 870.2600 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Salicylaldehyde
EC Number:
201-961-0
EC Name:
Salicylaldehyde
Cas Number:
90-02-8
Molecular formula:
C7H6O2
IUPAC Name:
salicylaldehyde
Details on test material:
Name of test material (as cited in study report): Salicylaldehyde - Physical state: clear, colorless, oily liquid - Analytical purity: over 95 %

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: epicutaneous; drop on
Vehicle:
no data
Concentration / amount:
1%
Challenge
Concentration / amount:
1%
No. of animals per dose:
5 animals (In the table attached to the report, the number of animals was 4. For this inconsistency between the text and table, no explanation was given in this report)
Positive control substance(s):
yes
Remarks:
Phenylhydrazine

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
1%
No. with + reactions:
0
Total no. in group:
5
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 5.0.

Applicant's summary and conclusion