Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation
Remarks:
other: read across from analogy
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The target chemical should be classified as Aldehyde AND Aryl by Organic Functional groups (extended)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Guideline:
other: read-across by QSAR toolbox
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Salicylaldehyde
EC Number:
201-961-0
EC Name:
Salicylaldehyde
Cas Number:
90-02-8
Molecular formula:
C7H6O2
IUPAC Name:
salicylaldehyde
Constituent 2
Reference substance name:
4-(methylthio)benzaldehyde
EC Number:
222-365-7
EC Name:
4-(methylthio)benzaldehyde
Cas Number:
3446-89-7
IUPAC Name:
4-(methylsulfanyl)benzaldehyde
Constituent 3
Reference substance name:
4-formylbenzoic acid
EC Number:
210-607-4
EC Name:
4-formylbenzoic acid
Cas Number:
619-66-9
IUPAC Name:
4-formylbenzoic acid
Details on test material:
CAS number:3446-89-7
Chemical name(s):4-(methylsulfanyl)benzaldehyde

CAS number: 619-66-9
Chemical name(s): 4-formylbenzoic acid

Test animals / tissue source

Species:
rabbit

Results and discussion

In vivo

Results
Irritation parameter:
other: MMAS
Time point:
other: 3d
Score:
ca. 25
Reversibility:
not specified

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU

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