Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test was conducted according to OECD test guideline in compliance with GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Salicylaldehyde
EC Number:
201-961-0
EC Name:
Salicylaldehyde
Cas Number:
90-02-8
Molecular formula:
C7H6O2
IUPAC Name:
2-hydroxybenzaldehyde
Details on test material:
Name of test material (as cited in study report):2-hydroxybenzaldehyde - Purity: > 97.0% - Impurity: Water, < 0.2 %- Lot/batch No.: FGC01 - Stability under test conditions: IR chromatogrammes were measured before and after the experiment. - Storage condition of test material: Cool place

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.66
Temp.:
25 °C
pH:
6.2 - 6.3
Remarks on result:
other: The pH value naturally occured during testing

Any other information on results incl. tables

Kow

Log Kow

Average

pH

Condition 1

a

4.63E1

1.67

1.67

6.2

b

4.74E1

1.68

6.2

Condition 2

a

4.59E1

1.66

1.66

6.2

b

4.49E1

1.65

6.3

Condition 3

a

4.59E1

1.66

1.66

6.3

b

4.53E1

1.66

6.3

Applicant's summary and conclusion

Conclusions:
partition coefficient between octanol and water (log Kow) is 1.66.