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EC number: 298-577-9 | CAS number: 93819-94-4
Test material MRD-80-22 was assessed for acute dermal toxicity in New Zealand White rabbits in a protocol similar to OECD guideline 402. Doses of the undiluted liquid were applied to the shaved skin of groups of two animals/sex at 50, 200, 794 or 3160 mg/kg bw under an occluded patch. After 24 hours, the patch was removed and the test site wiped free of excess test material. Observations were carried out during a 14-day period, after which the animals were subject to necropsy.
No deaths occurred during the study. At 200, 794 and 3160 mg/kg bw, several animals had soft faeces and faecal staining on some days throughout the study; however the number of animals involved and frequency of occurrence were not dose-related. All animals had gained in body weight at study termination, except two females at 794 mg/kg bw which showed no weight change. Changes observed at necropsy occurred in the majority of animals at all dose levels, but their severity did not appear to be dose-related. These changes included diminished and roughened spleens, red or tan coloured lungs, vascularized stomach and/or intestines and red foci in the adrenals. Erythema and edema was observed at all dose levels and tended to be dose-related in severity. Exfoliation of the skin was evident during the second week at the application site at the highest dose and skin necrosis was present in two of these animals.
In conclusion, under the test conditions, since the LD50 was considered >3160 mg/kg bw, MRD-80-22 would not be classified for acute dermal toxicity according to the EU CLP Regulations or the Dangerous Substances Directive.
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