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EC number: 298-577-9 | CAS number: 93819-94-4
These results demonstrate that under the conditions and temperature of the stomach, the basic form of
ZDDP is quickly converted to the neutral form. The basic form was converted to neutral within 5 minutes
(secondary) or 15 minutes (primary – likely slower than primary due to higher starting amounts of basic).
The chromatograms of the results are included in the illustrations section.
A critical question about the ZDDP chemical category is whether the amount of basic vs. neutral ZDDP
will influence the toxicity and, hence, wether this is a variable that requires consideration in e.g., the
boundary composition for the category. These results demonstrate that, upon ingestion, ZDDPs will
rapidly and completely convert from the basic form to the neutral form. This information is critical to
developing the Intelligent Testing Strategy for the ZDDP category because it demonstrates that the
basic form of ZDDPs are not relevant from a toxicity perspective. Specifically, upon ingestion there is
transformation of all ZDDPs to the neutral form which becomes the common denominator.
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