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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
The decarboxylation of some phenolic acids by the rat
Author:
Scheline, R.R.
Year:
1966
Bibliographic source:
Acta Pharmacol and Toxicol, 1966

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Pyrogallol was adiminister to 4 adult albno rats by stomach tube or ip injection (100 mg/khg). After 24 h , urine samples were collected, extracted with ether and analyzed by TLC. Some of them were hydrolized acidic hydrolysis) before analysis..
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
not specified
Details on test material:
Not specified

Test animals

Species:
rat
Strain:
other: albino

Administration / exposure

Route of administration:
other: oral:stomach tube or ip injection
Vehicle:
not specified
Details on exposure:
once
Doses / concentrations
Dose / conc.:
100 mg/kg bw/day
No. of animals per sex per dose:
4 total

Results and discussion

Main ADME results
Type:
metabolism
Results:
Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol

Applicant's summary and conclusion

Conclusions:
Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol
Executive summary:

When pyrogallol was administered by gavage or i.p. injection to albino rats (sex not provided) at 100 mg/kg (0.79 mmol/kg), unchanged pyrogallol, 2-O-methylpyrogallol, and traces of resorcinol were detected in the urine. Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol