Registration Dossier
Registration Dossier
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EC number: 201-762-9 | CAS number: 87-66-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Pyrogallol
- Author:
- CIR - COSMETIC INGREDIENT REVIEW
- Year:
- 1 991
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY. 10(1): 67-85
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test:
- Short description of test conditions:
- Parameters analysed / observed: - GLP compliance:
- not specified
Test material
- Reference substance name:
- Pyrogallol
- EC Number:
- 201-762-9
- EC Name:
- Pyrogallol
- Cas Number:
- 87-66-1
- Molecular formula:
- C6H6O3
- IUPAC Name:
- benzene-1,2,3-triol
- Reference substance name:
- unknown impurities
- IUPAC Name:
- unknown impurities
- Test material form:
- not specified
- Details on test material:
- not specified
Constituent 1
impurity 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Details on species / strain selection:
- no data
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 consecutives days
- Frequency of treatment:
- every day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.01 other: mMol
- Dose / conc.:
- 0.05 other: mMol
- No. of animals per sex per dose:
- 29
- Control animals:
- not specified
- Details on study design:
- no data
- Positive control:
- no data
Results and discussion
Any other information on results incl. tables
7 and 14 animals had sensitization reactions to 0.01 M and 0.05 M pyrogallol, respectively.
Of those animals receiving the challenge treatment as sealed cloth applications, 3 and 6 animals had sensitization reactions to 0.01 M and 0.05 M pyrogallol, respectively.
Applicant's summary and conclusion
- Conclusions:
- Some animals had sensitization reactions to the substance tested.
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