Registration Dossier

Administrative data

Endpoint:
appearance / physical state / colour
Type of information:
other: observation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of Pyrogallol
Author:
CIR - COSMETIC INGREDIENT REVIEW
Year:
1991
Bibliographic source:
JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY. 10(1): 67-85

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
- Principle of test: There is no guideline method for this endpoint. Data presented based on visual observation (supported by data on melting point)
- Short description of test conditions: an observation at standard temperature and pressure was performed.
- Parameters analysed / observed: physical state, color and odor of the substance.
GLP compliance:
not specified
Other quality assurance:
other: not specified
Remarks:
primary source: WINDHOLZ, M., BUDVARI, S., BLUMETTI, R.F., and OTTERBEIN, F.A. 119831. The Merck Index, 10th ed. Rahway, NJ: Merck and Co., Inc., p, 1154

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
not specified
Details on test material:
not specified
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: not specified
- Expiration date of the lot/batch: not specified
- Purity test date: not specified

RADIOLABELLING INFORMATION (if applicable) not applicable
- Radiochemical purity: -
- Specific activity: -
- Locations of the label: -
- Expiration date of radiochemical substance: -

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability under test conditions: not specified
- Solubility and stability of the test substance in the solvent/vehicle: not specified
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not specified

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: not relevant
- Preliminary purification step (if any): not specified
- Final dilution of a dissolved solid, stock liquid or gel: not relevant
- Final preparation of a solid: not relevant

FORM AS APPLIED IN THE TEST (if different from that of starting material) solid

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable) not applicable

OTHER SPECIFICS: Pyrogallol consists of a minimum of 99% Pyrogallol.
A UV spectral analysis of chemically pure (99%) Pyrogallol, 0.1% w/v in methanol, showed a single absorbance maximum at 267.5 nm

Results and discussion

Physical state at 20°C and 1013 hPa:
solid
Form / colour / odour
Key result
Form:
solid: crystalline
Remarks:
(crystals)
Colour:
white
Odour:
odourless
Substance type:
organic

Applicant's summary and conclusion

Conclusions:
Pyrogallol is an organic solid and ordorless at standard temperature and pressure.
Executive summary:

Pyrogallol is an organic solid and ordorless at standard temperature and pressure (@20°C and 1013 hPa).

No information on data or the test method used to measure this endpoint are available in the handbook. However, this information is taken from a peer reviewed handbook (primary source: The Merck Index, 10th ed) and mentioned in a high quality review so, it can be considered reliable and suitable for use as the key study for this endpoint

.