Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of Pyrogallol
Author:
CIR - COSMETIC INGREDIENT REVIEW
Year:
1991
Bibliographic source:
JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY. 10(1): 67-85

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative value for the property under investigation. The introduction to the Merck Index states that physical data are cited as found in the literature. When several alternate data values appear in the literature, the data is evaluated and representative selections are made; values are then reported with the corresponding source. Therefore, although the method used is not known, the values presented here are acceptable as they are from a reliable secondary source of phys chem. data.
- Short description of test conditions: not specified
- Parameters analysed / observed: Boiling Temperature
GLP compliance:
not specified
Other quality assurance:
other: not specified
Remarks:
primary source: WINDHOLZ, M., BUDVARI, S., BLUMETTI, R.F., and OTTERBEIN, F.A. 119831. The Merck Index, 10th ed. Rahway, NJ: Merck and Co., Inc., p, 1154
Type of method:
other: not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
not specified
Details on test material:
not specified
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: not specified
- Expiration date of the lot/batch: not specified
- Purity test date: not specified

RADIOLABELLING INFORMATION (if applicable)
not applicable


STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability under test conditions: not specified
- Solubility and stability of the test substance in the solvent/vehicle: not specified
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not specified

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: not relevant
- Preliminary purification step (if any): not specified
- Final dilution of a dissolved solid, stock liquid or gel: not relevant
- Final preparation of a solid: not relevant

FORM AS APPLIED IN THE TEST (if different from that of starting material)
solid

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable)
not applicable

OTHER SPECIFICS: Pyrogallol consists of a minimum of 99% Pyrogallol.
A UV spectral analysis of chemically pure (99%) Pyrogallol, 0.1% w/v in methanol, showed a single absorbance maximum at 267.5 nm

Results and discussion

Boiling point
Key result
Boiling pt.:
309 °C
Atm. press.:
101.3 kPa

Applicant's summary and conclusion

Conclusions:
The boiling point of pyrogallol is 309°C.
Executive summary:

The boiling point of pyrogallol is 309°C.

No information on data or the test method used to measure this endpoint are available in the handbook. However, the information are taken from a peer reviewed handbook (primary source: The Merck Index, 10th ed) and mentioned in a high quality review so, it can be considered reliable and suitable for use as the key study for this endpoint