Registration Dossier

Administrative data

Description of key information

Acute toxicity:
Oral: LD50: >2000 mg/kg bw for rat (limit test)
Inhalation: LC50 >0.244 mg/l for rat
Dermal: LD50: >3000 mg/kg bw for rabbit

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
244 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 000 mg/kg bw

Additional information

Based on the available data from acute oral toxicity study, Anthraquinone is non toxic if swallowed (LD50oral,rat is>2000 mg/kg bw).

Description of study on acute toxicity of Anthraquinone via inhalation route reported in IUCLID (February 19, 2000) was very brief and information was not sufficient for the assessment of human health. The inhalation study conducted by Industrial BIO-TEST Laboratories, Inc. stated the LC50(4h)>0.244 mg/l. The concentration of 0.244 mg/l air was maximum attainable concentration the animals were exposed to and there were no untoward reactions during exposure or the 14-day observation period which followed. Therefore Anthraquinone is regarded as non toxic if inhaled.

The results from acute dermal toxicity test indicated Anthraquinone as being a non toxic in contact with the skin (LD50dermal, rat is >3000 mg/kg bw).

Justification for classification or non-classification

Based on the test results and according to the EC criteria for classification and labelling requirements for dangerous substances and mixtures the test substance Anthraquinone did not fall into any of quoted categories of toxicity and has no obligatory labelling requirement in this respect.