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EC number: 201-549-0 | CAS number: 84-65-1
The test substance, Anthraquinone, was tested in the study for acute dermal irritation /corrosion. Rabbits (New Zealand Albino breed) were used for the test.
Test was performed according to Method B.4 - Acute Toxicity: Dermal Irritation/Corrosion, Council Regulation (EC) No.440/2008, published in O.J. L 142, 2008.
Three rabbits were exposed to 0.5 g of test substance, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Skin reactions were evaluated after patch removal and observations were made at 1, 24, 48 and 72 hours after exposure.
At first the test substance was applied on the skin of one rabbit (test animal No. 7). Rabbit No. 7 was investigated 3 minutes, 1 hour and 4 hours after application of the test substance. No symptoms of irritation were observed on the skin. In confirmatory test, two others rabbits (rabbit No. 8 and No. 9) were used with 4-hour exposition period. No evidence of a corrosive effect or symptoms of irritation were observed on the skin.
No skin irritation was caused by 4-hour exposure to Anthraquinone. No other signs of intoxication were observed.
Based on these results and according to the EC criteria for classification and labelling requirements for dangerous substances and preparations (Council Directive 67/548/EEC, Annex VI, part 22.214.171.124.), the test substance does not have to be classified for skin irritation and has no obligatory labelling requirement for skin irritation.
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