Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Concerning sensitisation, one study in animals (Local Lymph Node Assay) performed according to current standards and under GLP conditions was available. The test substance had a positive result in LLNA test after topical application to the mouse ear. Positive results in cell proliferation and no clinical symptoms of systemic toxicity revealed that the test substance Anthraquinone could be a contact allergen but potential irritation effect does not rule out the possibility that it could be a false positive result.

Migrated from Short description of key information:
Skin sensitisation:
Local Lymph Node assay (LLNA): positive results (EU Method B.42)

Justification for classification or non-classification

Based on the positive results of LLNA, Anthraquinone is classified as skin sensitiser and the risk phrase R43 May cause sensitisation by skin contact is assigned to Anthraquinone according to DSD criteria; according to Regulation (EC) No 1272/2008 criteria Anthraquinone is classified as skin sensitiser (Category 1) and hazard statement H317 May cause an allergic skin reaction is assigned.