Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No study of skin sensitisation is available for sodium permanganate. However, based on read-across from the closely-related substance potassium permanganate, the substance is considered to be corrosive. Testing for skin sensitisation is not justified on scientific grounds or for reasons of animal welfare. The local effects of dermal exposure to the substance will be dominated by irritation/corrosion and sensitisation is considered to be unlikely. In addition, it is noted that potassium permangante in dilute solution is used for the treatment and prevention of skin infections and no reports of sensitisation have been identified.

In addition a Magnusson and Kligman Guinea pig Maximisation test for delayed contact hypersensitivity was completed with potassium permanganate, giving negative results with no adverse dermal reactions observed. Read-across for sodium permanganate is acceptable for this data and the test substance is not considered to be a contact sensitiser.

Potassium permanganate has been used as a surrogate for sodium permanganate where data are not available. Read-across from potassium permanganate to sodium permanganate is appropriate from the toxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions. This toxicophore similarity is adequate justification for waiving the conduct of specific studies with sodium permanganate and the dossier reflects this waiving proposal by including summaries of read-across studies where appropriate.


Migrated from Short description of key information:
No data are available for sodium permanganate. The substance is assumed to be corrosive, therefore testing is not required. The local effects of dermal exposure will be dominated by irritation/corrosion and sensitisation is considered to be unlikely based on human experience.

A sensitisation study with the closely related material, potassium permanganate, showed no evidence of delayed contact hypersensitivity in a Magnusson and Klgman Maximisation test.
Potassium permanganate has been used as a surrogate for sodium permanganate where data are not available. Read-across from potassium permanganate to sodium permanganate is appropriate from the toxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions. This toxicophore similarity is adequate justification for waiving the conduct of specific studies with sodium permanganate and the dossier reflects this waiving proposal by including summaries of read-across studies where appropriate.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

There are no currently validated studies of respiratory sensitisation and no reports of occupational asthma in exposed workers. The local effects of inhalation exposure to sodium permanganate will be dominated by respiratory tract irritation and other efefcts are unlikely.


Migrated from Short description of key information:
No data are available.

Justification for classification or non-classification

No classification is proposed in the absence of any indication that the substance can cause sensitisation.