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EC number: 233-251-1 | CAS number: 10101-50-5
The results of a dermal irritation study indicate that the read-across substance potassium permanganate is corrosive. No data are available for eye irritation.Potassium permanganate has been used as a surrogate for sodium permanganate where data are not available. Read-across from potassium permanganate to sodium permanganate is appropriate from the toxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions. This toxicophore similarity is adequate justification for waiving the conduct of specific studies with sodium permanganate and the dossier reflects this waiving proposal by including summaries of read-across studies where appropriate.
Skin irritation study:
0.5 g of potassium permanganate was applied directly to the clipped, intact skin of the rabbit for 4 hours. A 14-day observation period followed application. Potassium permanganate applied at 0.5g caused full destruction of the skin tissue after 4 hours, therefore the testing was stopped and no further animals were used. No extinction of corrosive lesions was recorded following 72 hours after exposure, and during the 14 day observation period, the lesions on the skin were almost healed without complications. No other signs of intoxication were recorded. Based on the results the test substance Potassium permanganate is classified as corrosive and the risk phrase 'R34: causes burns' should be assigned. It is therefore also assumed that sodium permanganate is corrosive.
No study is available and none has been performed as the substance is considered to be corrosive.
Classification as corrosive (R34) is considered to be appropriate, based on the results of a study with the closely-related read-across substance potassium permanganate. Separate classification for eye irritation is considered implicit and is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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