Registration Dossier

Administrative data

Description of key information

The results of a dermal irritation study indicate that the read-across substance potassium permanganate is corrosive.  No data are available for eye irritation.
Potassium permanganate has been used as a surrogate for sodium permanganate where data are not available. Read-across from potassium permanganate to sodium permanganate is appropriate from the toxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions. This toxicophore similarity is adequate justification for waiving the conduct of specific studies with sodium permanganate and the dossier reflects this waiving proposal by including summaries of read-across studies where appropriate.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Additional information

Skin irritation study:

0.5 g of potassium permanganate was applied directly to the clipped, intact skin of the rabbit for 4 hours. A 14-day observation period followed application. Potassium permanganate applied at 0.5g caused full destruction of the skin tissue after 4 hours, therefore the testing was stopped and no further animals were used. No extinction of corrosive lesions was recorded following 72 hours after exposure, and during the 14 day observation period, the lesions on the skin were almost healed without complications. No other signs of intoxication were recorded. Based on the results the test substance Potassium permanganate is classified as corrosive and the risk phrase 'R34: causes burns' should be assigned. It is therefore also assumed that sodium permanganate is corrosive.

Eye irritation

No study is available and none has been performed as the substance is considered to be corrosive.

Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

Classification as corrosive (R34) is considered to be appropriate, based on the results of a study with the closely-related read-across substance potassium permanganate. Separate classification for eye irritation is considered implicit and is not required.