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EC number: 233-251-1 | CAS number: 10101-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.04-2006 - 21.04.2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to the appropriate guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Test substance concentrations measured in the test solution decreased by more than 20% during the test. This minor deviation did not affect the outcome of the study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- Test substance concentrations measured in the test solution decreased by more than 20% during the test. This minor deviation did not affect the outcome of the study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium permanganate
- EC Number:
- 231-760-3
- EC Name:
- Potassium permanganate
- Cas Number:
- 7722-64-7
- IUPAC Name:
- potassium oxido(trioxo)manganese
- Reference substance name:
- KMnO4
- IUPAC Name:
- KMnO4
- Details on test material:
- Appearance of potassium permanganate - Dark violet, purple crystalling powder with bronze lustre.
Batch number – 69
Impurities - manganese dioxide - cc 0.1%
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Potassium permanganate is being used as a surrogate for sodium permanganate. Read-across from potassium permanganate to sodium permanganate is appropriate from the ecotoxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Concentrations were verified analytically at the start and end of each 24 hour exposure period. Samples were stored at room temperature prior to analysis.
Fish mortality was observed every 24 hours and pH, temperature and dissolved oxygen was measured at the same intervals.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test material was soluble in water in the range of concentration tested.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Juveniles Daphnia magna Straus were obtained by parthogenesis from the laboratory breeding stock. Juveniles less than 24 hours old were used to initiate the study.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- The dilution water should have a sum value of Ca + Mg ions of 2.5 mmol/L. Measured values were 2.56 and 2.53 mmol/L at 0 and 24 hours.
- Test temperature:
- Measured range during the exposure period was 20.8 to 21.2
- pH:
- pH was measured as 7.8 in all test media over the duration of the study.
- Dissolved oxygen:
- Measured range was 8.1-8.3 mg/L
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations 0 (control), 0.01, 0.02, 0.04, 0.08, 0.16, 0.32 and 0.64 mg/L. It was not possible to measure concentrations below 0.16 mg/L., the limit of quantification was 0.05 mg/L and the limit of detexction was 0.015 mg/L. Measured concentrations at the start of each exposure period were found in the 0.16, 0.32 and 0.64 mg/L treatments, after the 24 hour exposure period it was only possible to measure the concentrations in the 0.64 mg/L treatment. The results of the study was basd on the nominal exposure concentrations.
- Details on test conditions:
- The study was conducted with two replicates each of 10 Daphnia.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.11-0.18 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.06 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.05-0.07 mg/L
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.02 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- The sensitivity of the Daphnia culture is periodically verified by testing the reference substance, potassium dichromate. The results of the verification test carried out in March 2006 gave a 48h EC50 of 0.65 mg/L (95% CI limits of 0.54 – 0.76 mg/L). This result is within the range for potassium dichromate provided by the Centre for Assessment of Laboratories of T.G. Masaryk Water Research Institute Prague in 2005 of between 0.49 – 1.37 mg/L.
- Reported statistics and error estimates:
- The NOEC and EC100 values were identified by direct observation. The EC50 values were calculated by means of software 'Toxicity' (product of Water Research Institute, Ostrava, Czech Republic. The nominal concentration of the test substance was used for all evaluations and results.
Any other information on results incl. tables
Measured test substance concentrations during the definitive study
Nominal Conc. (mg/L) | Determined conc. 0 hours [mg/L] | Determined conc. 24 hours Solution 1 [mg/L] | Determined conc. 24 hours Solution 2 [mg/L] | Determined conc. 48 hours Solution 2 [mg/L] |
0.01 | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) |
0.02 | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) |
0.04 | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) |
0.08 | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) | < LOQ (< LOD) |
0.16 | 0.0661 | < LOQ (< LOD) | 0.0992 | < LOQ (< LOD) |
0.32 | 0.1562 | < LOQ (< LOD) | 0.2507 | < LOQ (< LOD) |
0.64 | 0.5190 | 0.0780 | 0.5954 | 0.3297 |
LOD: Limit of detection (0.015 mg/L), LOQ: Limit of quantification (0.050 mg/L)
Cumulative immobilisation of Daphnia – definitive study
Nominal concentration (mg/L) | Cumulative % immobilisedDaphnia | |
24 hours | 48 hours | |
Control | 0 | 0 |
0.01 | 0 | 0 |
0.320.02 | 0 | 10 |
0.04 | 5 | 35 |
0.08 | 5 | 65 |
0.16 | 60 | 95 |
0.32 | 95 | 100 |
0.64 | 100 | 100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48 hour acute semi-static toxicity study with Daphnia magna was performed to assess the toxicity of potassium permanganate. The study was performed according to GLP and the OECD 202Test Guideline. The 48 hour EC50 was calculated to be 0.06 mg/L, with 95% confidence limits of 0.05 to 0.07 mg/L (based nominal exposure concentrations), the corresponding NOEC was 0.01 mg/L.
- Executive summary:
A 48 hour acute semi-static toxicity study withDaphnia magnawas performed to assess the toxicity of potassium permanganate. The study was performed according to GLP and the OECD 202Test Guideline. The 48 hour EC50 was calculated to be 0.06 mg/L, with 95% confidence limits of 0.05 to 0.07 mg/L (based nominal exposure concentrations), the corresponding NOEC was 0.01 mg/L.
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