Registration Dossier

Administrative data

Description of key information

The acute dermal LD50 of the read-across substance potassium permanganate is reported to be >2000 mg/kg bw.  Waivers are proposed for acute oral and inhalation toxicity as the substance is considered likely to be corrosive based on read-across from potassium permanganate.
Potassium permanganate has been used as a surrogate for sodium permanganate where data are not available. Read-across from potassium permanganate to sodium permanganate is appropriate from the toxicological point of view as the most toxicologically relevant part of the substances is the same (permanganate). The contribution of the sodium/potassium ions to the toxicity of the respective substances is likely to be minimal. The toxicity of both substances is therefore likely to be very similar and will be dominated by local (site of contact) irritant/corrosive effects and systemic toxicity due to the absorption of manganese ions. This toxicophore similarity is adequate justification for waiving the conduct of specific studies with sodium permanganate and the dossier reflects this waiving proposal by including summaries of read-across studies where appropriate.

Key value for chemical safety assessment

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
2 000 mg/kg bw

Additional information

The acute dermal LD50 of the read-across substance potassium permanganate is reported to be >2000 mg/kg bw (Dvorakova, 2006). Waivers are proposed for acute oral and inhalation toxicity as the substance is considered likely to be corrosive based on read-across from potassium permanganate. The acute effects of exposure to the substance are likely to be dominated by local effects; additional testing is therefore not appropriate on scientific grounds and for reasons of animal welfare.

Justification for classification or non-classification

The available data do not trigger the classification of sodium permangangate for acute toxicity.