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EC number: 233-251-1 | CAS number: 10101-50-5
Skin reactions in the experimental animal
Time after 4-hours exposure
Rabbit No 1
Full thickness destruction of skin tissue occurs
Lesion – dry, without discharge
Surroundings of the lesion – slight erythema, no oedema
Lesion – dry, crust, eschar formation
One female Albino New Zealand rabbit was used in this study. 0.5 g of potassium permanganate was applied directly to the clipped, intact skin of the rabbit for 4 hours. A 14-day observation period followed application. Potassium permanganate applied at 0.5g caused full destruction of the skin tissue after 4 hours, therefore the testing was stopped and no further animals were used. No extinction of corrosive lesions was recorded following 72 hours after exposure, and during the 14 day observation period, the lesions on the skin were almost healed without complications. No other signs of intoxication were recorded.
Based on the results the test substance Potassium permanganate is classified as corrosive and the risk phrase 'R34: causes burns' should be assigned.
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