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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on Cinnamyl formate
Author:
S.P. Bhatia, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S70–S73
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: Cinnamyl formate
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology,Volume 14, Supplement, Pages 659-893 (1976)
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Dermal Toxicity test was carried out to study the effects of Cinnamyl formate (104-65-4) on rabbits.
GLP compliance:
no
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl formate
EC Number:
203-223-3
EC Name:
Cinnamyl formate
Cas Number:
104-65-4
Molecular formula:
C10H10O2
IUPAC Name:
cinnamyl formate
Details on test material:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Cinnamyl formate
- Molecular formula :C10H10O2
- Molecular weight:162.187 g/mol
- Substance type:Organic
- Physical state:Colorless to slightly yellow liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
Duration of exposure : 24 hours
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
Total: 6 animals = 5000 mg/kg bw
Control animals:
not specified
Details on study design:
Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rabbits at 5000 mg/kg bw
Mortality:
No mortality was observed in treated rabbits at 5000 mg/kg bw
Clinical signs:
No clinical effects were observed
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be >5000 mg/kg bw,when 6 rabbits were treated occlusively with Cinnamyl formate (104-65-4) by dermal application for exposure of 24 hours.
Executive summary:

In acute dermal toxicity study, 6 Rabbits were treated with Cinnamyl formate (104-65-4) in the concentration of 5000 mg/kg bw by dermal application. No mortality was observed in treated rabbits at dose 5000 mg/kg bw.No clinical effects were observed.Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated occlusively with Cinnamyl formate (104-65-4) by dermal application for exposure of 24 hours.