Registration Dossier
Registration Dossier
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EC number: 203-223-3 | CAS number: 104-65-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw material monograph of cinnamyl formate
- Author:
- D. L. J. Opdyke
- Year:
- 1 972
- Bibliographic source:
- food and chemical toxicology 1972
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007) S1–S23
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate skin sensitization potential of cinnamyl formate on 25 human male volunteers.
- GLP compliance:
- not specified
- Type of study:
- other: human maximization test
- Justification for non-LLNA method:
- Not specified
Test material
- Reference substance name:
- Cinnamyl formate
- EC Number:
- 203-223-3
- EC Name:
- Cinnamyl formate
- Cas Number:
- 104-65-4
- Molecular formula:
- C10H10O2
- IUPAC Name:
- cinnamyl formate
- Details on test material:
- - Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid
Constituent 1
- Specific details on test material used for the study:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid
In vivo test system
Test animals
- Species:
- other: human
- Sex:
- male
- Details on test animals and environmental conditions:
- no data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: not specified
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% (2760 µg/cm2)
- Day(s)/duration:
- not specified
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- other: Not specified
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% (2760 µg/cm2)
- Day(s)/duration:
- not specified
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 25 male human volunteer
- Details on study design:
- No data available
- Challenge controls:
- not specified
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 4% (2760 µg/cm2)
- Total no. in group:
- 25
- Clinical observations:
- no skin reaction observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: non skin sensitizing
- Conclusions:
- Cinnamyl formate when applied on 25 male human volunteer did not gave any skin reaction after induction and challenge exposure. Cinnamyl formate can be considered as not sensitizing on human skin.
- Executive summary:
Cinnamylformate when used as a test material to evaluate its skin sensitization potential by human maximization test in concentration 4% (2760 µg/cm2) in petrolatum .Cinnamyl formate when applied on 25 male human volunteer .
It did not gave any skin reaction after induction and challenge exposure. Cinnamyl formate can be considered as not sensitizing on human skin.
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