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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw material monograph of cinnamyl formate
Author:
D. L. J. Opdyke
Year:
1972
Bibliographic source:
food and chemical toxicology 1972
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate skin sensitization potential of cinnamyl formate on 25 human male volunteers.
GLP compliance:
not specified
Type of study:
other: human maximization test
Justification for non-LLNA method:
Not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl formate
EC Number:
203-223-3
EC Name:
Cinnamyl formate
Cas Number:
104-65-4
Molecular formula:
C10H10O2
IUPAC Name:
cinnamyl formate
Details on test material:
- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid
Specific details on test material used for the study:
Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic
-physical state- colourless to yellowish liquid

In vivo test system

Test animals

Species:
other: human
Sex:
male
Details on test animals and environmental conditions:
no data available

Study design: in vivo (non-LLNA)

Induction
Route:
other: not specified
Vehicle:
petrolatum
Concentration / amount:
4% (2760 µg/cm2)
Day(s)/duration:
not specified
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
other: Not specified
Vehicle:
petrolatum
Concentration / amount:
4% (2760 µg/cm2)
Day(s)/duration:
not specified
Adequacy of challenge:
not specified
No. of animals per dose:
25 male human volunteer
Details on study design:
No data available
Challenge controls:
not specified
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
4% (2760 µg/cm2)
Total no. in group:
25
Clinical observations:
no skin reaction observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: non skin sensitizing
Conclusions:
Cinnamyl formate when applied on 25 male human volunteer did not gave any skin reaction after induction and challenge exposure. Cinnamyl formate can be considered as not sensitizing on human skin.
Executive summary:

Cinnamylformate when used as a test material to evaluate its skin sensitization potential by human maximization test in concentration 4% (2760 µg/cm2) in petrolatum .Cinnamyl formate when applied on 25 male human volunteer .

It did not gave any skin reaction after induction and challenge exposure. Cinnamyl formate can be considered as not sensitizing on human skin.

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