Cinnamyl formate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Fragrance material review on Cinnamyl formate

Author:

S.P. Bhatia, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api

Year:

2007

Bibliographic source:

Food and Chemical Toxicology 45 (2007) S70–S73

Reference 2

Reference Type:

publication

Title:

The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients

Author:

Timothy B. Adamsa, Samuel M. Cohenb, John Daulle, Victor J. Ferond, Jay I. Goodmane, Lawrence J. Marnettf, Ian C. Munrog, Philip S. Portogheseh, Robert L. Smithi, William J. WaddeW, Bernard M. Wagnerk

Year:

2004

Bibliographic source:

Food and Chemical Toxicology 42 (2004) 157-185

Reference 3

Reference Type:

publication

Title:

Monographs on Fragrance Raw Materials: Cinnamyl formate

Author:

D. L. J. Opdyke

Year:

1976

Bibliographic source:

Food and Cosmetics Toxicology,Volume 14, Supplement, Pages 659-893 (1976)

Reference 4

Reference Type:

publication

Title:

Acute oral toxicity study of Cinnamyl formate (104-65-4) in Rat

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

Chemidplus Database,U.S. National Library of Medicine ,2017

Reference 5

Reference Type:

publication

Title:

A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients

Author:

D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami

Year:

2007

Bibliographic source:

Food and Chemical Toxicology, 45, (2007) S1–S23

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute Oral toxicity test was carried out to study the effects of Cinnamyl formate (104-65-4) on rats.

GLP compliance:

not specified

Test type:

other: No data available

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Cinnamyl formate

EC Number:

203-223-3

EC Name:

Cinnamyl formate

Cas Number:

104-65-4

Molecular formula:

C10H10O2

IUPAC Name:

cinnamyl formate

Details on test material:

- Name of test material (IUPAC name): Cinnamyl formate
- Common name: 3-Phenylallyl formate
- Molecular formula: C10H10O2
- Molecular weight: 162.187 g/mol
- Smiles notation: c1(\C=C\COC=O)ccccc1
- InChl: 1S/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report):Cinnamyl formate
- Molecular formula :C10H10O2
- Molecular weight :162.187 g/mol
- Substance type:Organic
- Physical state:Colorless to slightly yellow liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No data available

Doses:

2000, 2500, 3200, 4000 and 5000 mg/kg/bodyweight

No. of animals per sex per dose:

Total: 50 animals
2000 mg/kg/bw = 10 animals
2500 mg/kg/bw =10 animals
3200 mg/kg/bw =10 animals
4000 mg/kg/bw =10 animals
5000 mg/kg/bw =10 animals

Control animals:

not specified

Details on study design:

Details on study design
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Clinical signs

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 900 mg/kg bw

Based on:

test mat.

95% CL:

> 2 380 - < 3 540

Remarks on result:

other: 50% mortality was observed

Mortality:

At 2000 mg/kg bw - 1 rat died.
At 2500mg/kg bw - 4 rats died.
At 3200 mg/kg bw - 7 rats died.
At 4000 mg/kg bw - 9 rats died.
At 5000 mg/kg bw - 9 rats died.

Clinical signs:

other: Clinical signs like ataxia and mucoid enteritis were observed

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2900 mg/kg bw(95% C.I. 2380–3540 mg/kg) ,when 50 rats were treated with Cinnamyl formate (104-65-4) orally.

Executive summary:

Acute Oral Toxicity study was performed in 50 rats using test material Cinnamyl formate (104-65-4). 50% Mortality was observed at dose 2900 mg/kg bw. A majority of the deaths occurred between days 1 and 2.Clinical signs like ataxia and mucoid enteritis were observed. Hence,LD50 value was considered to be 2900 mg/kg bw(95% C.I. 2380–3540 mg/kg),when rats were treated with Cinnamyl formate (104-65-4)orally.