Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1979
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment (no data on doses/concentrations).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
10 day repeated open application to guinea pig
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Diisobutyl Ketone
- Physical state: liquid
- Analytical purity: 65%
- Impurities (identity and concentrations): 32-35% 2-heptanone-4, 6-dimethyl

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
open
Vehicle:
not specified
Details on exposure:
TEST MATERIAL
- Concentration (if solution): no data
Duration of treatment / exposure:
10 days
No. of animals per sex per dose:
5

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

On day 1 slight to moderate erythema in 4 out of 5 animals On day 10 slight to moderate erythema in 4/5, slight edema in 5/5, eschars in 5/5. Repeated application exacerbates response. The insufficient data, especially on the concentration of the test substance, allows no classification.

Applicant's summary and conclusion

Conclusions:
The insufficient data, especially on the concentration of the test substance, allows no classification.