Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A 48-hour static acute test evaluated the toxicity of DIBK to the cladoceran, Daphnia magna.  The test followed OECD 202 and meet GLP 
requirements. The reported 48-hour EC50 value was 37.2 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
37.2 mg/L

Additional information

Two acute toxicity studies were available for 2,6-dimethylheptan-4-one (also known as diisobutyl ketone or DIBK) exposed to the freshwater cladoceran, Daphnia magna. A 2005 GLP study evaluated the toxicity of DIBK, followed OECD guidelines (OECD 203) and was rated a Klimisch score of 1, therefore it was selected as the Key study. The reported 48-hour EC50 value was 37.2 mg/L. An acute toxicity study, rated a Klimsch score of 2, was included as a supporting study. This supporting study was conducted prior to GLP requirements and followed guidelines outlined in Standard Methods. This supporting study reported a 48-hour EC50 value of 164 mg/L.