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EC number: 203-620-1 | CAS number: 108-83-8
Starting point for the DNEL calculations is the Inhalation 2 year study in rats.
The NOAEC from this study is taken as 2650 mg/m3 (following molar conversion from MIBK to DIBC)
Bioavailability: 100% is assumed for all 3 routes.
This is likely an over estimate however the physical chemical properties (log Kow, water sol, MW, vapour pressure, absence of charge) indicate that this substance would be bioavailable via all three routes. It is likely that oral availability is higher and that although bioavailable via dermal route, the rate of absorption would be lower than inhalation and oral such that there would be kinetic differences that may modify the toxicity (dermal being less toxic).
An additional assessment factor of 2 has been utilised in deriving the DNELs due to the use of read across. This factor is not being used because of a suspicion that the read across is not 100% reliable. Rather, it is being used to address the uncertainty in associated with the trend in toxicity across the group of substances.
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