Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-620-1 | CAS number: 108-83-8
Categories
- Category name:
- Isobutyl Ketones and Carbinols
Justifications and discussions
- Category definition:
- Isobutyl ketones and their corresponding carbinol metabolites. The primary purpose of the read across is for the repeated dose and reproductive/developmental toxicity endpoints.
- Category description:
- Methyl Isobutyl Ketone, Methyl Isobutyl Carbinol, Diisobutyl ketone, diisobutyl Carbinol
- Category rationale:
- The rationale is 2 fold:
1) The Isobutyl Ketones have the same isobutyl ketone functional group and a common metabolic pathway to the isobutyl carbinols as deomonstrated by the available metabolism data. The metabolism data also deomonstrates the carbinols are metabolised back to the ketones.
2) The available toxicity data on each substance for the repeated dose and reproductive developmental toxicity demonstrate a high level of consistency across the group, with the same target organs being affected (liver and kidney) and a low order of reproductive/developmental effects.
Due to the structural similarities, the similarities in metabolic pathways it is justified to group these substances together for the prupose of read across.
Other isobutyl ketones may also fit into this category, however there are currently no other substances identified that have data on the reproductive/developmental endpoints that could form the basis of a read across.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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