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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A 96-hour flow through acute test evaluated the toxicity of DIBK to the rainbow trout.  The test followed OECD 203 and meet GLP requirements.  The reported 96-hour LC50 value was 30 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
30 mg/L

Additional information

Two acute toxicity studies were available for 2,6-dimethylheptan-4-one (also known as diisobutyl ketone or DIBK) exposed to fish. A 2005 study evaluated the toxicity of DIBK to rainbow trout in a 96-hour flow through exposure. This GLP study followed OECD guidelines (OECD 203) and was rated a Klimisch score of 1, therefore it was selected as the Key study. The reported 96-hour LC50 value was 30 mg/L. A static acute toxicity study, rated a Klimsch score of 2, was included as a supporting study. This supporting study was conducted prior to GLP requirements and followed guidelines outlined in Standard Methods. This supporting study reported a 96 -hour LC50 value of >150 mg/L, the highest dose level tested.