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EC number: 203-628-5 | CAS number: 108-90-7
Groups of 30 males and 30 females CD rats, designed as P generation, were exposed to vapor of monochlorobenzene (MCB) at target concentrations of 0 , 50 , 150, or 450 ppm (0, 234, 702 or 2106 mg/m³) for 10 weeks prior to mating and during mating, gestation, and lactation. The progeny of the P generation was designed as the F1 generation and groups of 30 male and 30 female F1 animals were exposed to the same concentration of MCB as the F0 parents. Exposure of F1 animals was initiated 1 week postweaning and lasted 11 weeks prior to the mating and through mating, gestation, and lactation. All F2 pups were observed through weaning at which time they were killed. Observations made during the study included body weights, food consumption, mating and fertility indices, pup and litter survival indices, and histopathology of selected tissues.
No mortality was observed during the course of this study. No adverse effect of treatment was evident on body weight, food consumption, and physical observation. Overall, reproductive performance, fertility and development of pups were not affected by treatment with monochlorobenzene yielding a NOAEC of 450 ppm (corresponding to 2106 mg/m³) for reproduction and development.
However, post mortem examinations revealed significantly elevated absolute and relative liver weights in F0 and F1 male and female rats at 150 and 450 ppm and at 50 ppm in F1 males accompanied by hepatocellular hypertrophy in F0 and F1 males exposed to 150 and 450 ppm. In addition, renal changes (tubular dilation with eosinophilic material, interstitial nephritis, and foci of regenerative epithelium) were observed mainly in F0 and F1 male rats exposed to 150 and 450 ppm. The significance of reported degeneration of the testicular germinal epithelium in male rats at 450 ppm is unclear because no histopathological correlate is reported. Thus, the LOAEC (systemic toxicity) is considered to be 50 ppm (corresponding to 234 mg/m³).
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